Night of Champions was a pay-per-view (PPV) event produced by WWE, which took place on September 16, 2012 at the TD Garden in Boston, Massachusetts. It was presented by Lions Gate Entertainment's Dredd and was the fifth annual WWE Night of Champions event (sixth including Vengeance: Night of Champions) and the thirteenth in the WWE Vengeance/Night of Champions overall chronology. The theme to the Night of Champions event is that all sanctioned championships are defended on the card. The event managed to gain 189,000 buys. That is up from last year's event, which gained a 169,000 buyrate.
- PreShow - Zack Ryder won by last eliminating Tensai - 16-man battle royal for a WWE United States Championship match later that night
- The Miz (c) defeated Rey Mysterio, Cody Rhodes andSin Cara - Fatal 4-Way match for the WWE Intercontinental Championship
- Team Hell No (Kane and Daniel Bryan) defeated R-Truth and Kofi Kingston (c) for the WWE Tag Team Championship
- Antonio Cesaro (c) (with Aksana) defeated Zack Ryder for the WWE United States Championship
- Randy Orton defeated Dolph Ziggler (with Vickie Guerrero)
- Eve Torres defeated Layla (c) for the WWE Divas Championship
- Sheamus (c) defeated Alberto Del Rio (with Ricardo Rodriguez and David Otunga) for the WWE World Heavyweight Championship
- CM Punk (c) (with Paul Heyman) vs. John Cena ended in a draw for the WWE Championship