Fastlane was a pay-per-view and WWE Network event produced by WWE for Raw and SmackDown. It took place on March 21, 2021, and was broadcast from the WWE ThunderDome, hosted at Tropicana Field in St. Petersburg, Florida—it was the final pay-per-view held at Tropicana Feld, as beginning April 12, the ThunderDome would relocate to Yuengling Center in Tampa, Florida. It was the sixth event under the WWE Fastlane chronology and the first since 2019. It was the first event to also stream via Peacock's WWE Network channel in the United States, and the last to be available on the standalone version of the WWE Network in the U.S., as beginning April 5, U.S. subscribers would only be able to access the WWE Network via Peacock.
- KickOff - Riddle (c) defeated Mustafa Ali (with Mace, Reckoning, Slapjack, and T-Bar) for the WWE United States Championship
- Nia Jax and Shayna Baszler (c) (with Reginald) defeated Bianca Belair and Sasha Banks for the WWE Women's Tag Team Championship
- Big E (c) defeated Apollo Crews for the WWE Intercontinental Championship
- Joseph Average defeated R-Truth for the WWE 24/7 Championship
- R-Truth defeated Joseph Average for the WWE 24/7 Championship
- Braun Strowman defeated Elias (with Jaxson Ryker)
- Seth Rollins defeated Shinsuke Nakamura
- Drew McIntyre defeated Sheamus - No Holds Barred match
- Alexa Bliss defeated Randy Orton - Intergender match
- Roman Reigns (c) (with Paul Heyman) defeated Daniel Bryan for the WWE Universal Championship - Edge was the special guest enforcer.