Lockdown 2010 was a professional wrestling pay-per-view (PPV) event produced by the Total Nonstop Action Wrestling (TNA) promotion, which took place on April 18, 2010 at the Family Arena in Saint Charles, Missouri. It was the sixth event under the Lockdown chronology and the fourth event of the 2010 TNA PPV schedule. In the tradition of Lockdown events, every match took place inside a steel cage. And the first lockdown event with a four sided steel cage.
- Rob Van Dam defeated James Storm in a Steel Cage match for the numbers advantage in the Lethal Lockdown match
- Homicide defeated Alex Shelley, Chris Sabin and Brian Kendrick in an Xscape match to join the TNA X Division Championship match
- Kevin Nash defeated Eric Young in a Steel Cage match
- The Beautiful People (Madison Rayne and Velvet Sky) (c) (with Lacey Von Erich) defeated Angelina Love (c) and Tara via pinfall (by Madison Rayne, who becomes new Knockouts Champion) in a Steel Cage match for the TNA Knockouts Championship and TNA Knockouts Tag Team Championship
- Kazarian defeated Shannon Moore and Homicide in a Steel Cage match for the TNA X Division Championship
- Team 3D (Brother Ray and Brother Devon) defeated The Band (Kevin Nash and Scott Hall) in a St. Louis street fight Steel Cage match
- Kurt Angle defeated Mr. Anderson in an Xscape Steel Cage match
- A.J. Styles(c) defeated D'Angelo Dinero in a Steel Cage match for the TNA World Heavyweight Championship
- Team Hogan (Team Captain Abyss, Jeff Jarrett, Jeff Hardy, and Rob Van Dam) defeated Team Flair (Team Captain Sting, Beer Money, Inc. (Robert Roode and James Storm), and Desmond Wolfe) in a Lethal Lockdown. If Team Flair won, Hulk Hogan would leave the company.