Genesis (2006) was a pay-per-view (PPV) event produced by Total Nonstop Action Wrestling (TNA), which took place on November 19, 2006 at the TNA Impact! Zone in Orlando, Florida. It was the second event under the TNA Genesis chronology. Eight matches were featured on the event's card.
- Pre-Show match: Robert Roode (w/Ms. Brooks) defeated Eric Young
- Pre-Show match: Eric Young defeated Robert Roode (w/Ms. Brooks) - This rematch happened after referee Rudy Charles learned that Roode had cheated in the previous match.
- The Voodoo Kin Mafia (B.G. James and Kip James) defeated Kazarian, Maverick Matt and Johnny Devine
- The Naturals (Andy Douglas and Chase Stevens) (w/Shane Douglas) defeated Sonjay Dutt and Jay Lethal (w/Jerry Lynn)
- Christopher Daniels defeated Chris Sabin to retain the TNA X Division Championship
- Ron Killings and Lance Hoyt defeated The Paparazzi (Austin Starr and Alex Shelley) (w/Kevin Nash)
- Christian Cage defeated A.J. Styles
- The Latin American Exchange (Homicide and Hernandez) (w/Konnan) defeated America's Most Wanted (Chris Harris and James Storm) (w/Gail Kim) to retain the NWA World Tag Team Championship - After the match, Jim Cornette came out and stripped LAX of the Tag Team Titles due to their actions leading up to the PPV - a decision that was later reversed.
- Abyss (w/James Mitchell) defeated Sting by disqualification to win the NWA World Heavyweight Championship
- Kurt Angle defeated Samoa Joe
